Breast density in NF1 women: a retrospective study.

Neurofibromatosis type 1 (NF1) is an autosomal dominant condition caused by neurofibromin haploinsufficiency due to pathogenic variants in the NF1 gene. Tumor predisposition has long been associated with NF1, and an increased breast cancer (BC) incidence and reduced survival have been reported in recent years for women with NF1. As breast density is another known independent risk factor for BC, this study aims to evaluate the variability of breast density in patients with NF1 compared to the general population. Mammograms from 98 NF1 women affected by NF1, and enrolled onto our monocentric BC screening program, were compared with those from 300 healthy subjects to verify differences in breast density. Mammograms were independently reviewed and scored by a radiologist and using a Computer-Aided Detection (CAD) software. The comparison of breast density between NF1 patients and controls was performed through Chi-squared test and with multivariable ordinal logistic models adjusted for age, body mass index (BMI), number of pregnancies, and menopausal status.breast density was influenced by BMI and menopausal status in both NF1 patients and healthy subjects. No difference in breast density was observed between NF1 patients and the healthy female population, even after considering the potential confounding factors.Although NF1 and a highly fibroglandular breast are known risk factors of BC, in this study, NF1 patients were shown to have comparable breast density to healthy subjects. The presence of pathogenic variants in the NF1 gene does not influence the breast density value.

[Clinical efficacy of nimesulide compared to diclofenac sodium in the prevention and treatment of postoperative pain-inflammation symptomatology]. / Efficacia clinica della nimesulide in confronto a diclofenac sodico nella prevenzione e nel trattamento della sintomatologia algico-flogistica postchirurgica.

In a double blind, controlled clinical study, 40 patients, 20 of whom were subjected to mastectomy or quadrantectomy and 20 to inguinal hernioplasty, were randomly assigned to two treatment groups of 20 subjects each, balanced by type of operation. Treatment lasted 3 days and involved the administration of 3 suppositories per day of nimesulide or diclofenac sodium. Independently of the type of operation, a significant reduction in pain symptomatology (spontaneous pain, pain on active and passive movements) and in inflammatory symptomatology (hyperaemia and tumefaction) and a good control of body temperature was observed for both treatment groups. No changes in arterial pressure or laboratory examinations were observed in either group, nor there were any noteworthy adverse reactions.